Macaroni and Cheese with Buttery Crumbs

Name: Macaroni and Cheese with Buttery Crumbs
Ingredients: 5 tablespoons unsalted butter, divided, plus more for greasing the baking dish; 3 tablespoons all-purpose flour; 2 1/2 cups half-and-half or whole milk; 1 pound sharp cheddar cheese, cut into 1/2-inch pieces, divided; 1/2 pound Colby cheese, cut into 1/2-inch pieces, divided; 1 tablespoon Dijon mustard; Pinch of freshly grated nutmeg; Pinch of cayenne pepper; Kosher salt; Freshly ground black pepper; 1 pound elbow macaroni; 3/4 cup plain dry breadcrumbs